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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC8
All Species:
22.73
Human Site:
Y100
Identified Species:
31.25
UniProt:
Q9BY41
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY41
NP_060956.1
377
41758
Y100
S
I
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Chimpanzee
Pan troglodytes
XP_001140380
415
46624
Y138
S
I
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Rhesus Macaque
Macaca mulatta
XP_001093861
377
41783
Y100
S
I
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Dog
Lupus familis
XP_538078
377
41675
Y100
S
V
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8VH37
377
41753
Y100
S
I
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Rat
Rattus norvegicus
Q4QQW4
482
55074
E98
M
Q
R
F
N
V
G
E
D
C
P
V
F
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510728
773
87357
Y394
S
V
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Chicken
Gallus gallus
P56517
480
54920
E98
M
Q
R
F
N
V
G
E
D
C
P
V
F
D
G
Frog
Xenopus laevis
O42227
480
54874
E98
M
Q
R
F
N
V
G
E
D
C
P
V
F
D
G
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
P98
G
G
D
C
P
V
F
P
G
L
F
E
F
C
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
C98
R
F
N
V
G
E
D
C
P
V
F
D
G
L
Y
Honey Bee
Apis mellifera
XP_394976
461
52425
L114
S
V
A
A
A
V
K
L
N
K
Q
A
S
E
I
Nematode Worm
Caenorhab. elegans
O17695
461
52119
G101
Q
M
L
K
F
N
V
G
E
D
C
P
L
F
D
Sea Urchin
Strong. purpuratus
P56518
576
64060
C99
R
F
N
V
G
E
D
C
P
V
F
D
G
L
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
G111
L
L
K
R
F
N
V
G
E
E
C
P
V
L
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
F99
L
G
E
D
C
P
V
F
E
D
L
F
E
F
C
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
G107
E
S
V
K
F
N
V
G
D
D
C
P
V
F
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
99.1
97.6
N.A.
96.2
32.7
N.A.
44.2
32.5
33.3
37.3
N.A.
30.1
35.1
34.4
27.7
Protein Similarity:
100
87.7
99.7
99.1
N.A.
98.1
50.2
N.A.
47.3
50
50.6
56.3
N.A.
46.6
54
51.4
42.3
P-Site Identity:
100
100
100
93.3
N.A.
100
33.3
N.A.
93.3
33.3
33.3
0
N.A.
6.6
20
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
53.3
N.A.
100
53.3
53.3
13.3
N.A.
6.6
46.6
13.3
6.6
Percent
Protein Identity:
N.A.
33.3
N.A.
38.5
36.4
N.A.
Protein Similarity:
N.A.
48.1
N.A.
57.2
55.4
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
6
6
0
0
0
0
0
0
42
0
0
0
% A
% Cys:
0
0
0
6
6
0
0
12
0
53
18
0
0
6
6
% C
% Asp:
0
0
6
6
0
0
12
0
59
18
0
12
0
18
18
% D
% Glu:
6
0
42
0
0
12
0
18
18
6
0
6
6
42
0
% E
% Phe:
0
12
0
18
18
0
6
6
0
0
18
6
24
18
0
% F
% Gly:
6
12
0
0
48
0
53
18
6
0
0
0
12
0
53
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
6
% I
% Lys:
0
0
6
12
0
0
6
0
0
6
0
0
0
0
0
% K
% Leu:
12
6
6
0
0
36
0
6
0
6
6
0
6
18
0
% L
% Met:
18
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
12
0
18
18
0
0
6
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
6
6
0
6
12
0
53
18
0
0
0
% P
% Gln:
6
18
0
0
0
0
0
0
0
0
6
0
0
0
0
% Q
% Arg:
12
0
18
6
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
42
6
0
0
0
0
0
0
0
0
0
0
6
0
6
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
36
0
0
% T
% Val:
0
18
6
12
0
30
24
0
0
12
0
18
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
36
0
0
0
36
0
0
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _